Financial toxicity greater among heart disease patients compared to those with cancer

Daily News Egypt
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Financial toxicity, the financial strain experienced by patients accessing healthcare, impacts a large population of cancer patients, a previous research has shown.

A new study, published in JACC: CardioOncology, finds financial toxicity is often greater among heart disease patients compared to cancer patients, and those with both conditions suffer the highest burden.

Dr Khurram Nasir, Chief of the Division of Cardiovascular Prevention and Wellness at Houston Methodist DeBakey Heart and Vascular Center and senior author of the paper, said, “Heart disease and cancer are the leading causes of death in the United States, yet most research on financial toxicity has focused on cancer patients.”

He added, “It is important to consider that cancer patients may have short bursts of high expenditures for treatments, while heart disease patients are often incurring a more chronic economic burden due to drug costs, procedures, clinician visits and hospital stays.”

As the rate of cancer survival grows, the population of patients with both heart disease and cancer is growing, Nasir said, adding that the financial burden created by these diseases manifests as another form of affliction.

“Without the ability to pay, our patients can suffer from financial, health and non-health related difficulties that the healthcare field must be prepared to address,” he noted, “It does very little good if we can treat the cancer or the heart disease, but the patient cannot afford to eat or pay their mortgage.”

Financial toxicity is defined as having any of the following: difficulty in paying medical bills; inability to pay them at all; high financial distress; cost-related medication non-adherence; food insecurity; and/or delayed/foregone care due to cost.

Using data from the National Health Interview Survey from 2013-2018, researchers included 141,826 non-elderly adults aged between 18 and 65 years. Of these, 6,887 had cancer, and 6,093 had atherosclerotic cardiovascular disease (ASCVD), whilst 971 had both.

The study used a self-reported diagnosis of coronary disease, cerebrovascular disease and/or cancer. Researchers only included non-elderly adults in their main analysis, to capture the population without universal financial protections from public insurance such as Medicare. Similar findings, however, were reported in the Medicare population as well.

A nationally representative survey

The National Health Interview Survey is conducted by the National Center for Health Statistics and Centers for Disease Control and Prevention (CDC). As a weighted survey, it is a nationally representative survey.

It contains four components: Household Composition; Family Core; Sample Child Core; Sample Adult Core. The Household Composition collects basic information and relationship information about all persons in a household.

The Family Core component collects sociodemographic characteristics, basic indicators of health status, activity limitations, injuries, health insurance coverage, and access to and utilization of health care services.

For the Sample Child and Sample Adult Core, one child and one adult are randomly selected to gather more detailed information. The study utilised the Sample Adult Core information with relevant information from the Household and Family Core components.

Researchers supplemented these with demographic and socioeconomic characteristics, health status, health care services and health-related behaviours in the US adult population.

Most individuals with cancer and/or ASCVD in the study population were 40-64 years old, insured, and white. Female participants were more likely to report having cancer, with a majority coming from middle-/high-income households and with a higher education level.

Those reporting ASCVD, with or without cancer, were evenly distributed by sex, education, and income levels but had a more unfavourable cardiovascular risk profile. The most reported cancers included non-melanoma skin, breast, cervix, prostate, and “other” cancers, which was also seen among those reporting both ASCVD and cancer.

Any financial toxicity was more likely to be present in patients with both ASCVD and cancer, than those with ASCVD, those with cancer, and those with neither cancer nor ASCVD, respectively. Difficulty paying bills was significantly higher for ASCVD patients with and without cancer compared to patients with only cancer.

Facing financial toxicity

Overall, the same pattern (ASCVD and cancer – ASCVD – cancer – neither) was observed for high financial distress, cost-related medication non-adherence, food insecurity and delayed/foregone medical care due to cost, when compare those reporting ASCVD with or without cancer versus cancer.

Patients with both cancer and ASCVD had increased odds of experiencing any financial toxicity measured in the study. In a sub-analysis of elderly patients, the same pattern was observed for all financial toxicity measures at significantly lower rates.

“There is an urgent need for effective methods to alleviate financial toxicity for heart disease and cancer patients,” Nasir said, “In the current health system, there are already small- and large-scale strategies to identify and combat financial toxicity.”

He added, “This has already been observed among oncologists when prompted to talk to their patients about financial burden in the office.”

It is especially important for clinicians who care for patients with heart disease and/or cancer, given the high economic burden facing these patients, he noted.

Meanwhile, Dr Javier Valero-Elizondo from the Division of Cardiovascular Prevention and Wellness at Houston Methodist DeBakey Heart and Vascular Center and lead author of the paper, said, “The current manuscript gives us an overall picture of the economic burden suffered by patients with heart disease and/or cancer on a national level, and to tackle the two top causes of mortality in the US, we have to more aggressively consider the financial toxicity associated with both these diseases, and their treatment.”

He said, “While this study is amongst the first of its kind, we hope it helps not only to build on current literature, but also serve as an idea generating paper to fight financial toxicity.”

Study limitations include the self-reported nature of ASCVD and/or cancer and the limited number of financial toxicity features evaluated.

It also takes into account that the National Health Interview Survey assessed whether anyone in the household had financial hardship. This precluded assessment of the proportion of medical bills directly related to ASCVD and/or cancer and their contribution to financial hardship.

The researchers also noted that possible strategies to mitigate financial toxicity in cancer patients have started to yield positive results, which may be reflected in the analysis.

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